The play, An Inspector Calls is written by J.B Priestley Essay Example for Free

The play, An Inspector Calls is written by J.B Priestley Essay The play, An Inspector Calls is written by J. B Priestley. It was written in 1945 and set in 1912, just before World War One. The play is all set in the Birling household in Bromley. In the play the Birlings and Gerald Croft are celebrating the engagement of Sheila Birling and Gerald. The are all celebrating in a self-satisfied way. Arthur Birling is telling Eric and Gerald about every man should be for himself and that everyone should look out for themselves and their families. There is a knock on the door and Inspector Goole bears the news of a young woman who died in an infirmary from drinking disinfectant. The Inspector slowly implicates all of the Birlings and Gerald into the suicide of the girl, Eva Smith. Mr. Birling fired Eva from her job, as she wanted a small pay-rise. Sheila got Eva fired from a job in Milwards by using her social power just because she was jealous of her. Gerald had met her and gave her a place to stay, but had then left her after a while. Eric had met her in a pub and then made love to her and got her pregnant; he then stole money from his father, Arthur to help support her. Mrs. Birling then turned Eva down from her help community and made sure no one else listened to Evas story. The Inspector made everyone confess to what they had done to contribute to Evas death. After the Inspector left, Arthur and Gerald realised that the Inspector wasnt really an Inspector. They all thought they were in the clear when the phone rang and the real police said there was a girl dead in an infirmary, and that the police were on there way to the Birling household for an interview. At that point the play ends. The structure is that it consists of three acts and it is set in real time, so the time it takes for story to unfold is the same time it takes the audience to watch the play. It also has a unity of place and action, so it is all in the same place (the Birling household) and so is the action. I think it is set like this to give the audience help in understanding the morality of the play, which is We are all members of one body, we are all responsible for each other. Priestleys main aims about responsibility is that he is saying everyone is responsible for everyone else, and that you cannot just care about yourself, the opposite of what Arthur Birling thinks. He demonstrates this by slowly making all the characters partly responsible for Evas death, and as a whole all the characters drove Eva to her death. So Priestley is teaching the characters a lesson as well as the audience watching. At the beginning of the play Priestley makes Arthur say a man has to mind his own business and look after himself but after the play the Inspector comes in Priestley contradicts what Arthur said by making all the characters partly responsible for Evas death. Priestley sets the play in real time so both the audience and characters can experience the feelings and emotions of the play at the same time. In the play, Priestley has made Arthur a man who believes in only looking out for yourself and your family only. Arthur makes out to be a man who can do as he pleases just because of his social and business position. Priestley also makes Arthur say things like -the Titanic- she sails next week-forty-six thousand eight hundred tons-New York in five days-and every luxury-and unsinkable Priestley made Arthur say this knowing full well that the Titanic was sinkable and did sink! I think Priestley is trying to make out about how wrong Arthur is on many aspects of life and that he is also wrong in thinking every man for himself.

Ethical Justification: Involving Human Volunteers in Trials

Ethical Justification: Involving Human Volunteers in Trials Ethical Justification of Involving Human Volunteers in Phase 1 Trials Zoheb Rafique INTRODUCTION Tremendous development in recent medical science and the consequent discoveries resulting in successful prevention and also cure of different diseases are shared by clinical research involving the human volunteers. Preceding the trials in the human subjects, and to ensure safety, the proposed drug and other interventions are either tested in animals (vivo) or in laboratory (vitro) to evaluate initial safe starting dose for the human beings and to key out the benchmarks for the clinical monitoring for the potential unfavorable effects. These pre human trials might not necessarily protect against the untoward effects in the human beings as happened in the case of thalidomide tragedy, which caused disability and killed thousands of babies born to the mothers, those who took this medicine. Use of healthy human volunteers in the preliminary experiments or phase I clinical trials either reduces or excludes risks of subsequent undesirable effects in the future trails (1). Phase-1 trials are conducted in order to test the safety, reactions and immunogenicity of vaccines in volunteers. Novel treatments for the cancer are first tested in phase 1 trials enrolling the patients with advanced disease, who have exhausted the standard treatment options. Phase-1 oncology trials are the pivot point in the translation of new cancer therapies from bench to bedside. Nevertheless, these trials remain ethically controversial. The controversy stems from the fact that, classically, phase-1 oncology clinical trials involve first-in-human testing of experimental treatment candidates in patients with a terminal diagnosis, who typically have exhausted standard treatment options. Commentators on the ethics of phase-1 clinical trials make diametrically opposed claims about the prospect of direct medical benefit from participation in these trials-benefits that can be attributed to receiving the experimental treatment intervention. One camp of benefit skeptics, inhabited mainly by bioethicists , characterizes this form of research as lacking any reasonable prospect of direct medical benefit. They see an ethical cloud hovering over phase-1 trials, because the vast majority of patients volunteer for phase-1 trials out of a motivation to receive medical benefit. In the view of these skeptics, such patients therefore harbor a ‘therapeutic misconception’ about research participation. This misconception calls into question the validity of informed consent and thereby undercuts the ethical basis of these trials (2). In this paper, I will discuss the ethical justification of the participation of human volunteers in phase-1 trials. DISCUSSION It is now widely accepted that medical research designed for the benefit of populations in developed countries should not be conducted with subjects recruited from populations in economically underdeveloped countries. Indeed, it is ethically objectionable to recruit from populations in resource-poor settings, even in developed countries, unless those populations are particularly susceptible to the condition the research is designed to relieve. In one study, there was proposal to conduct a phase-1 vaccine study recruiting subjects from the United States when the purpose is to assist the population of Mali, in Sub-Saharan Africa, to overcome the pervasive local consequences of Malaria. The ethical principle of justice, which requires a fair allocation of the risks and benefits of medical research, provides that the risk of research should not be planned to affect subjects from one population when benefits of the research are primarily directed to another population. It may accordingly appear, at first assessment, that the Malian government’s requirement that all phase-1 testing of the antimalarial vaccine be conducted in the United States is as unethical as it would be for the United States government to require that all phase-1 testing of a vaccine or other product intended primarily to benefit the population of the United States be conducted in Mali. Yet codes of ethical conduct are less consistent on this point than commentators usually require being. The World Medical Association’s much-cited Declaration of Helsinki: Ethical principles for Medical Research Involving Human subjects provides that â€Å"Medical research is only justified if there is a reasonable likelihood that the population in which the research is carried out stand to benefit from the results of the research.† By this criterion, conduct of the phase-1 study in the United States appears unethical. In the context of HIV/AIDS, however, the WHO’S Global program on AIDS (1989) provided that, â€Å"in general, initial phase-1 trials should be conducted in the country of origin of the vaccine†. By this criterion, phase-1 testing in the United States is appropriate, if a vaccine would originate and initially be governmentally approved in the United States. The situation would be otherwise, of course, if the NIH was funding the study for production of the vaccine in Mali. The ethical remains of where the initial phase-1 vaccine trials can be conducted most equitably, with least risk of exploitation and most protection of the interests of study subjects (3). Most clinical research trials today require the informed consent. Concern however is raised that subjects of phase 1 trial studies might not provide valid consent. In particular, few commentators worry that subjects of phase 1 oncology trials have an exaggerated idea of any chance of the therapeutic benefit. The Empirical studies tells that phase 1 trial participants are highly optimistic an d hopeful about their chance of personal benefit and also are motivated by hope for the clinical improvement. Altruism, on other hand is much less often identified as driving the decision to enroll, when quoted as motivating factor; and it typically is not the prime reason for the participation. In one research study, sixty one (61 %) of phase 1 oncology participants were doubtful about altruism would motivate the advanced cancer patients to enroll in the non beneficial research and several phase 1 volunteers in another study showed â€Å"Surprise† at idea of research participation based exclusively on altruism. Some studies find, however that the individuals in some other types of research trials often participate in the hope of helping others. As an example, schaeffer and colleagues describe that â€Å"hope others benefit† is one of the two most common motivational factors for the healthy volunteers (4). The research participants should be fully informed about the di fference between research and therapy and also risk-benefit ratio. The researcher should offer patients substitutes other than participation in the trials and also vulnerable population should not be included in the trials at any cost and especially in the phase-1 trials. CIOMS guideline 7 talks about inducement of participation in research. According to the guideline the research subjects can be reimbursed for their needs such as transport and other expenses, and also lost earnings, that is associated with participation in the research. Those persons who receive no any direct benefit from research may also get a small amount of money for their inconvenience due to the participation in research. All volunteers may get the medical services unrelated to research and could have tests and procedures performed free of cost. Payments in terms of money or in kind to the research subjects may not be so huge as to carry them to take unwarranted risks or volunteer against the better judgment. Incompetent persons are vulnerable to the exploitation for financial gain by the guardians. A subject who withdraws himself/herself from the research for various reasons related to research study, such as unacceptable side-effects of a study drug, or who is withdrawn on health grounds, should be paid or recompensed as if full participation had taken place. For all biomedical research involving human subjects, the investigator must ensure that potential benefits and risks are reasonably balanced and risks are minimized. The Declaration of Helsinki deals with the wellbeing of research subjects and the avoidance of risk. Thus, considerations related to the well-being of the human subject should take precedence over the interests of science and society, clinical testing must be preceded by adequate laboratory or animal experimentation to demonstrate a reasonable probability of success without undue risk, every project should be preceded by careful judgment of predictable burden and ris ks in comparison with the foreseeable benefits to research subjects or to others; physician-researchers must be confident that the risks involved have been adequately assessed and can be satisfactorily managed; and the risks and burdens to the subject must be minimized, and reasonable in relation to the importance of the objective or the knowledge to be gained (5). CONCLUSION The first basic principle of the Declaration of Helsinki requires biomedical research involving human subjects to be based on â€Å"adequately performed laboratory and animal experimentation and on a thorough knowledge of the scientific literature.† This implies that human subjects should not be used unless and until successful experiments in animals, as well as in vitro, have been completed. The Declaration, like most consensus documents formulated by representatives of different nations and medical traditions, is often vague and difficult to interpret in specific cases. It might allow proceeding to clinical trials if adequate animal studies demonstrated the inapplicability irrelevance, or absence of a useful animal model. If animals died immediately after receiving a vaccine, this would undoubtedly prohibit using the vaccine in human subjects (6). I will conclude this paper by saying that research is the only way of getting rid of various diseases through proper treatment an d also benefiting future patients from those diseases which have no cure at present or any medical treatment available, so research should not be stopped. In my opinion, human volunteers can be involved in phase-1 trials but following all international guidelines and all other aspects of biomedical ethics. REFERENCES Inayat Ullah Memon. JUSTIFICATION OF PARTICIPATION OF HUMAN SUBJECTS IN PHASE 1 CLINICAL TRIALS: AN ETHICAL ANALYSIS. Bangladesh Journal of Bioethics 2011; 2(2):26-29 Franklin G Miller and Steven Joffe. Benefit in phase 1 oncology trials: therapeutic misconception or reasonable treatment option? Clinical Trials. 2008; 5: 617-623. Bernard Dickens. Reverse Exploitation in the Baltimore Malaria Vaccine Study. Emily Abdoler, Holly Taylor, and David Wendler. The Ethics of Phase 0 Oncology Trials. Clin cancer Res. 2008; 14(12): 3692-3697. International Ethical Guidelines for Biomedical Research Involving Human Subjects. CIOMS 2002; 1-113. Wendy K. Mariner. Why Clinical Trials of AIDS Vaccines Are Premature. Public Health and the Law. AJPH. 1989; Vol. 79, No. 1: 86-91.

Hamlet Essay -- essays research papers

During Shakespeare’s play Hamlet, the main character Hamlet has to deal with the responsibility of revenging his father’s murder. He learns of his tragic death when the ghost of King Hamlet comes to him and tells him the truth of his murder: he was killed by his brother Claudius, for his crown and his wife. Hamlet decides that the best plan of action is to fake madness to attain his father’s vengeance by murdering Claudius. As the play develops, Hamlets act of being a madman becomes more and more believable, and his friends and family react as you’d expect someone who is discovering that their loved one is slowly turning insane would. As we read the play and begin to understand Hamlet’s mentality, his inner thoughts, and the reasons for his actions, it becomes clear to the reader that Hamlet is, in fact, totally and healthily sane. It becomes evident that he is simply simulating insanity so that it is easier to fulfill his duties to his father, and that Claudius’s murder doesn’t rest so guiltily on his conscience. Hamlet only feigns madness because it allows him to do and say things that he otherwise could not say without severe repercussions and suspicion being held against him. It also prevents people from blaming him for his ridiculous antics, and from taking him seriously. We first see Hamlet’s initial plan of faking insanity falling into place when he is talking to Horatio and Marcellus, telling them not to comment to anyone about his â€Å"antic disposition (Shakespeare, 75).† Hamlet’s supposed madness allows him to talk to his friends, family, and especially to Ophelia in a manner that is totally unsuitable for a human being to act, especially a prince. He is completely disrespectful and insulting in his remarks, and although his antic disposition backfires while he is talking to his mother, it allows him to severely reprimand her actions and criticize her for her disloyalty to her deceased husband because Gertrude thinks he is insane. She therefore is very passive in her response to Hamlet, being very dismissive of his actions and harsh words because of his supposed insanity. Throughout the play, Hamlet also makes some very sexually inappropriate remarks to Ophelia such as â€Å"That’s a fair thought to lie between a maids` legs (Shakespeare, 157).† He can inappropriately vent his anger toward Ophelia for her abandonment in any way he pleases, being emotion... ...the play sane, normal, healthy, loving, but with the discovery of his father’s murder and his mother’s remarriage, he dies selfish, distraught, and cold-hearted. His feigned madness is maintained throughout the entire play because it allows him to follow through with his plans, which makes Hamlet not only completely sane, but truly genius. Maybe Hamlet thought too much, but he thought (and acted) as only a sane man could. He commits no actions whatsoever without much thought and reason, and he is far too organized, particular, and articulate to be proclaimed insane. His one downfall is also responsible of his many successes: his intelligence. Hamlet thinks far too much and has too much of a conscience to behave as a madman would, and going on a murdering rampage to kill Claudius. His hesitation in doing so is the main key that allows the reader to realize that Hamlet’s insanity is a complete farce, used to help Hamlet to maximize his father’s revenge a gainst Claudius in the most efficient and effective way possible, leaving few repercussions for Hamlet. Hamlet’s portrayal of a mad man is also very complicated because it not only gets his point made, but in a believably insane way.

He think he Jesus :: essays research papers

It was a typical day as any other with the only exception that it was nearly 50 degrees in the middle of December. People were operating as they always due skating through their business day while they sip on their Starbucks and yell at someone on their cell phone. But hey, that’s the world we live in, blank stairs, exchanging un-pleasantry’s and so on and so forth. Kids like me sit at tables trying to make some kind of pointless conversation with an attractive female while we stair into their eyes trying to figure out which words will get you laid up with them the fastest. All is moving fine until your plan is interrupted. Not by your â€Å"game† of course, never that, but by this bummy looking older man who decides to sit at the same table.   Ã‚  Ã‚  Ã‚  Ã‚  Ã¢â‚¬Å"Do you need help with your chemistry homework?† He asks my potential prey and points to her chemistry book that has been opened to the same page for the past 20 minutes. He wears a look of confidence despite his tattered fashion and yellow teeth. Now I am not one too big on believing in stereotypes, however, I call it how I see it and he looked like a bum, point blank. He began to speak about the basics of chemistry while sipping on coffee heavily saturated in sweet and low. As he began to speak and shed light on this topic, he flipped the conversation to history and the lies we’ve all been told. Everything he was saying I was familiar with, however I could tell he was shocking the female that was sitting across from me. At this point I realized that she had become a lost cause for the moment since she was very enthralled by our new acquaintance. In the midst of the truths he was speaking, he rambled a great deal as if he couldn’t mainta in a single thought long enough to fully explain it. He then began to denounce the importance of money, however he bragged about the diamonds from exotic countries that he owned. He carried a paper bag that was pretty full. As he began to dig in it to as if to prove himself, he pulled out so called skins from different animals around the world. They were supposedly worth a great deal of money and he was carrying them since he was awaiting a business meeting.

Sympathy for the Monster in Frankenstein by Mary Shelley :: essays research papers

In this essay I am going to answer ‘how and why does Mary Shelley make the reader sympathise with the character of the monster in her novel Frankenstein’. Many readers have sympathised with Frankenstein’s creation, the unnamed monster, because he is badly treated by most people who he comes across. Victor created the monster with dead body parts that he got though grave robbing once he got all of the parts it took him 2 years to build a body. Victor is very obsessed with his work because he would not let any one help him or see him his fiancà ©e is very worried he might be doing something he would regret. When victor brings the monster to life he soon realises that he has made a big mistake because he says ‘What have I done?’ this tells us that Victor has pride in his work at first but then it quickly turns to disbelief then he becomes terrified he leaves the monster and goes to his home in Geneva. The monster soon realises that he has been abandoned (I think that Mary has put in her novel him getting abandoned because her father abandoned her because he didn’t like the person who she was going to get married to) so he sets of to see what the world has to offer. As the monster comes across a village that has just been outrun with a deadly disease called colleria so when the villages see him they think that he brought it in and they beat. He turns to find Victor and make him pay for bring him back ugly. The monster finds a place to hide from all the people and he helps out a family by helping them with their farm work and he learns to read and write. In the fami ly there is a blind man the monster is very protective over the blind man and the man come for the tax on the house where they live and he beats the blind man up but then the monster beats up the tax man and the little girl with the blind man screams and the mum and dad hears meanwhile the blind man and the monster

Investigate the effect of one factor on the boiling temperature of a liquid Essay

Salt (NaCl) is a substance with a low vapour pressure. In comparison to any type of liquid, salt still has a lower vapour pressure. If salt was to be dissolved in water (H2O), in this case for the experiment, then consequently the salt will cause the overall vapour pressure of the solution to decrease and have a lower vapour pressure. Lowering a solution’s vapour pressure means that the solution will have a higher molecule vaporising point then pure water (without added salt). In other words, the boiling point of the solution will increase and therefore have a higher boiling point temperature. A term used to describe this outcome is also known as boiling-point elevation. [1] In this experiment the affect of table salt on the boiling point of tap water will be measured. Pure tap water without table salt added will be the control of this experiment and all results will be compared to the results of the pure tap water. The temperature of the water will be measured in degrees Celsius (à ¯Ã‚ ¿Ã‚ ½C) and the amount of table salt added will be measured in grams (g). This experiment will be carried out at Standard Lab Conditions (SLC); Research Question: How does table salt affect the boiling point of water? Hypothesis: It is hypothesised that adding table salt will cause the water to boil at a higher temperature. Variables: Independent variables: The amount of table salt added to water. (g) * 0 grams (control) * 10 grams * 20 grams * 30 grams * 40 grams * 50 grams Dependent variables: The temperature of water when it boils (à ¯Ã‚ ¿Ã‚ ½C) Controlled variables: Controlled variables How it will be controlled The conditions of the surrounding area (temperature, wind, humidity etc) of where the experiment is carried out The experiment will be carried out on one day only and at standard lab conditions Avoid salt residues left on the thermometer when testing water temperature Distilled water will be used to clean the thermometer before every testing of water The type of water used for the experiment Tap water for the science lab will be used for this experiment The point at which the water temperature will be recorded The temperature of the water will be recorded when the whole surface of the water is boiling and bubbling The length of time the thermometer is left in the beaker of water The thermometer will be left for 30 seconds in the beaker, to show clear results of the water temperature The depth at which the thermometer is left in the beaker The end tip of the beaker will be placed right at the centre bottom of the beaker The Bunsen burner flame that will heat the beaker The heat of the blue flame will boil the water in the beaker The length of time the Bunsen burner is left undisturbed on blue flame to reach its optimum temperature When the Bunsen burner safe flame is changed to blue flame, the Bunsen burner will be left on the bench undisturbed for 2 minutes The repetition and speed of stirring the solution When the beaker is placed onto the tripod with the blue flame on, immediately 5 slow circle rotations of the stirring rod will be performed to dissolve the salt into the water The amount of water used for this experiment For this experiment, 500 millimetres of water will be measured in the beakers. When measuring the water level, the observer must get down to eye level to avoid parallax error and misreading of the water level Avoiding contaminations to the equipment used in this experiment Before using equipments, distilled water will be used to thoroughly clean all equipments to avoid contamination and residues The brand and type of table salt used for this experiment Woolworths Iodated Table Salt will be used for this experiment The accuracy of measuring small amount of salt The sampler spoon will be filled with salt right to the top, (touching the edges but not overflowing) with salt. 2. A wash bottle was used to thoroughly clean all equipments of this experiment. Including: beakers, graduated cylinder; thermometer, stirring rod 3. With a permanent marker pen, each beaker was labelled (near the top mouth of the beaker): Control; 10g; 20g; 30g; 40g; 50g; respectively, in relation to the amount of salt that will be added to the water 4. The graduated cylinder was used to measure 500mL of tap water, and the tap water was then placed into a beaker. This was repeated until all six beakers were filled with 500mL of tap water 5. The sampler spoon was used to weigh the amount of table salt that each beaker of water needed according to the labels of the beakers Eg; If the beaker is labelled 30g, then 30g of salt must be added to the beaker. Which means salt will have to be scooped three times with the spoon 6. The Bunsen burner was set up and the safe flame was left on. The tripod was placed directly above the flame 7. When the Bunsen burner was changed to the blue flame, the stopwatch was used to record 2 minutes of the flame left undisturbed 8. The beaker that read Control was immediately placed onto the tripod after two minutes was up 9. The stirring rod was instantly retrieved and 5 slow circle rotations were performed to dissolve the salt into the water 10. The beaker was left stable on the tripod. Whilst waiting for the water to boil, changes to the solution was carefully observed. Observations were recorded as qualitative data. When the whole surface of the water boiled, the tip of the thermometer was immediately placed at the centre of the beaker for 30 seconds. The degree of the water was then recorded. 11. In avoiding dangers, the blue flame was changed to the safe 12. The beaker tongs was used to remove the beaker from the tripod and the beaker was then placed away from the experiment area 13. The wash bottle was used to clean residues off the thermometer. 14. Steps 7-12 was then repeated for the rest of the beakers labelled; 10g; 20g; 30g; 40g; 50g 15. In obtaining more accurate results, the whole experiment was carried out another three times and the average was then calculated: Test 1 result + Test 2 result + Test 3 result Bibliography 1. How Does Salt Affect the Boiling Point of Water. David Bradley. 27 Dec 2006. 07 Feb 2009. http://www.sciencebase.com/science-blog/how-does-salt-affect-the-boiling-point-of-water.html

Classic Pen Company: Developing an Abc Model

ANALYSIS Background Information: The Classic Pen Company was a low-cost producer of traditional BLUE and BLACK pens with profit margins over 20% of sales. They then introduced RED pens at a 3% premium, and a year later they introduced PURPLE pens due to the 10% premium that they could command. However, they were disappointed with the most recent year; RED and PURPLE pens were not bringing in expected sales (still considering their higher profit margin), and BLUE and BLACK pens profitability was down.Issue(s) Identification There are two main issues within this case: -Profitability -Pricing ?Which involves Production time and effort per unit. -Should they introduce even more variety? Can they keep up with demand and competition? Recommendations: 1. Get rid of RED pens – They are the trickiest to make; their revenue is only $. 03 more than standard pens. 2. Lower the Price for BLACK pens, since they are the most simple to make and require less overhead and direct labour. . Lower price of BLUE pens- they are the most popular, but with the changing market prices must be adjustable. 4. Invest in new equipment (Therefore eliminating time to clean vats in order to make new coloured pens). 5. Focus in only making BLUE and BLACK pens as specialty pens Conclusion: My recommendation to Dempsey would be to invest in new technology to lower the overhead costs (Set-ups, runs) in the future. With a competitive market it is important to adapt.The addition of new colours is crucial to their survival, but with the current machinery it may not be possible. New equipment would mean limited backlog (if any), more options in colour, and meeting customers’ demands. If investment of new machinery is not doable for the company, it would be best to try and cut cost, and focus on standard pens for future investments. BLACK and BLUE pens bring in the most sales volumes and they could potentially cut back to 200% overhead once again.